Assay Detail
Functional
CHEMBL640325
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Inhibition of adenylate cyclase via adenosine A1 receptors in rat fat cell membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.51 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319387 | — | — | 1 | 5.64 |
| CHEMBL2113496 | — | — | 1 | 5.54 |
| CHEMBL2113510 | — | — | 1 | 5.52 |
| CHEMBL2113507 | — | — | 1 | 5.47 |
| CHEMBL410873 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319387 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2113496 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL2113510 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2113507 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL410873 | — | IC50 | = | 4380.0 | nM | 5.36 |