Assay Detail
Functional
CHEMBL640336
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Effective concentration required for prolongation of the stimulus-QRS interval by 50% of the maximum response at the Adenosine A1 receptor in langendorff guinea pig heart preparation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-aralkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 4.77 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606082 | — | — | 1 | 5.20 |
| CHEMBL605668 | — | — | 1 | 5.13 |
| CHEMBL605878 | — | — | 1 | 4.94 |
| CHEMBL605667 | — | — | 1 | 4.93 |
| CHEMBL604836 | — | — | 1 | 4.89 |
| CHEMBL2311197 | — | — | 1 | 4.84 |
| CHEMBL605873 | — | — | 1 | 4.79 |
| CHEMBL604422 | — | — | 1 | 4.79 |
| CHEMBL605461 | — | — | 1 | 4.73 |
| CHEMBL606305 | — | — | 1 | 4.60 |
| CHEMBL605250 | — | — | 1 | 4.45 |
| CHEMBL605465 | — | — | 1 | 4.37 |
| CHEMBL605048 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606082 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL605668 | — | EC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL605878 | — | EC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL605667 | — | EC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL604836 | — | EC50 | = | 12882.5 | nM | 4.89 |
| CHEMBL2311197 | — | EC50 | = | 14454.4 | nM | 4.84 |
| CHEMBL605873 | — | EC50 | = | 16218.1 | nM | 4.79 |
| CHEMBL604422 | — | EC50 | = | 16218.1 | nM | 4.79 |
| CHEMBL605461 | — | EC50 | = | 18620.87 | nM | 4.73 |
| CHEMBL606305 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL605250 | — | EC50 | = | 35481.34 | nM | 4.45 |
| CHEMBL605465 | — | EC50 | = | 42657.95 | nM | 4.37 |
| CHEMBL605048 | — | EC50 | = | 46773.51 | nM | 4.33 |