Assay Detail
Functional
CHEMBL640337
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Prolongation of the stimulus-QRS interval by 50% of the maximum response at the Adenosine A1 receptor in langendorff guinea pig heart preparation
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.17 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112181 | — | — | 1 | 8.27 |
| CHEMBL605469 | — | — | 1 | 7.47 |
| CHEMBL464859 | NECA | — | 1 | 7.20 |
| CHEMBL1688963 | ISOGUANOSINE | — | 1 | 5.94 |
| CHEMBL605879 | — | — | 1 | 5.66 |
| CHEMBL603588 | — | — | 1 | 5.58 |
| CHEMBL603373 | — | — | 1 | 5.35 |
| CHEMBL605466 | — | — | 1 | 4.86 |
| CHEMBL604429 | — | — | 1 | 4.80 |
| CHEMBL604223 | — | — | 1 | 4.64 |
| CHEMBL331372 | CGS-21680 | — | 1 | 4.61 |
| CHEMBL604009 | — | — | 1 | 4.45 |
| CHEMBL603379 | — | — | 1 | 4.43 |
| CHEMBL605464 | — | — | 1 | 4.34 |
| CHEMBL603374 | — | — | 1 | 4.20 |
| CHEMBL604224 | — | — | 1 | 4.18 |
| CHEMBL604844 | — | — | 1 | 4.10 |
| CHEMBL2311200 | — | — | 1 | 4.10 |
| CHEMBL605472 | — | — | 1 | 4.00 |
| CHEMBL605679 | — | — | 1 | - |
| CHEMBL604838 | — | — | 1 | - |
| CHEMBL606510 | — | — | 1 | - |
| CHEMBL604426 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112181 | — | EC50 | = | 5.37 | nM | 8.27 |
| CHEMBL605469 | — | EC50 | = | 33.88 | nM | 7.47 |
| CHEMBL464859 | NECA | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1688963 | ISOGUANOSINE | EC50 | = | 1148.15 | nM | 5.94 |
| CHEMBL605879 | — | EC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL603588 | — | EC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL603373 | — | EC50 | = | 4466.84 | nM | 5.35 |
| CHEMBL605466 | — | EC50 | = | 13803.84 | nM | 4.86 |
| CHEMBL604429 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL604223 | — | EC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL331372 | CGS-21680 | EC50 | = | 24547.09 | nM | 4.61 |
| CHEMBL604009 | — | EC50 | = | 35481.34 | nM | 4.45 |
| CHEMBL603379 | — | EC50 | = | 37153.52 | nM | 4.43 |
| CHEMBL605464 | — | EC50 | = | 45708.82 | nM | 4.34 |
| CHEMBL603374 | — | EC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL604224 | — | EC50 | = | 66069.34 | nM | 4.18 |
| CHEMBL604844 | — | EC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL2311200 | — | EC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL605472 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL605679 | — | EC50 | = | 891250.94 | nM | - |
| CHEMBL604838 | — | EC50 | = | 107151.93 | nM | - |
| CHEMBL606510 | — | EC50 | = | 147910.84 | nM | - |
| CHEMBL604426 | — | EC50 | = | 223872.11 | nM | - |