Assay Detail
Functional
CHEMBL640338
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Prolongation of the stimulus-QRS interval by 50% of the maximum response at the adenosine A1 receptor in langendorff guinea pig heart preparation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.45 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 7.90 |
| CHEMBL285819 | — | — | 1 | 6.72 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 5.47 |
| CHEMBL605254 | — | — | 1 | 5.43 |
| CHEMBL2094089 | — | — | 1 | 5.25 |
| CHEMBL605247 | — | — | 1 | 5.06 |
| CHEMBL606093 | — | — | 1 | 5.06 |
| CHEMBL2311198 | — | — | 1 | 5.03 |
| CHEMBL1256672 | — | — | 1 | 4.90 |
| CHEMBL603589 | — | — | 1 | 4.85 |
| CHEMBL605673 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL285819 | — | EC50 | = | 190.55 | nM | 6.72 |
| CHEMBL477 | ADENOSINE | EC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL605254 | — | EC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL2094089 | — | EC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL605247 | — | EC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL606093 | — | EC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL2311198 | — | EC50 | = | 9332.54 | nM | 5.03 |
| CHEMBL1256672 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL603589 | — | EC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL605673 | — | EC50 | = | 50118.72 | nM | 4.30 |