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Assay Detail

CHEMBL640339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Adenosine receptor A1 (CHEMBL2304404)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

2-(N'-alkylidenehydrazino)adenosines: potent and selective coronary vasodilators.
Niiya K, Olsson RA, Thompson RD, Silvia SK, Ueeda M.
J Med Chem (1992) 35 : 4557 -4561
PubMed 1469687 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 4.85 5.45

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1950554 BINODENOSON 3.0 1 5.45
CHEMBL607873 1 5.44
CHEMBL611607 1 5.14
CHEMBL611919 1 5.05
CHEMBL608663 1 5.01
CHEMBL611314 1 4.96
CHEMBL607585 1 4.94
CHEMBL607877 1 4.92
CHEMBL87459 1 4.91
CHEMBL607599 1 4.90
CHEMBL609231 1 4.87
CHEMBL611921 1 4.78
CHEMBL607796 1 4.76
CHEMBL610444 1 4.70
CHEMBL610443 1 4.69
CHEMBL2113592 1 4.68
CHEMBL314313 1 4.64
CHEMBL611916 1 4.60
CHEMBL610727 1 4.60
CHEMBL611917 1 4.59
CHEMBL608966 1 4.18

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1950554 BINODENOSON EC50 = 3548.13 nM 5.45
CHEMBL607873 EC50 = 3630.78 nM 5.44
CHEMBL611607 EC50 = 7244.36 nM 5.14
CHEMBL611919 EC50 = 8912.51 nM 5.05
CHEMBL608663 EC50 = 9772.37 nM 5.01
CHEMBL611314 EC50 = 10964.78 nM 4.96
CHEMBL607585 EC50 = 11481.54 nM 4.94
CHEMBL607877 EC50 = 12022.64 nM 4.92
CHEMBL87459 EC50 = 12302.69 nM 4.91
CHEMBL607599 EC50 = 12589.25 nM 4.90
CHEMBL609231 EC50 = 13489.63 nM 4.87
CHEMBL611921 EC50 = 16595.87 nM 4.78
CHEMBL607796 EC50 = 17378.01 nM 4.76
CHEMBL610444 EC50 = 19952.62 nM 4.70
CHEMBL610443 EC50 = 20417.38 nM 4.69
CHEMBL2113592 EC50 = 20892.96 nM 4.68
CHEMBL314313 EC50 = 22908.68 nM 4.64
CHEMBL611916 EC50 = 25118.86 nM 4.60
CHEMBL610727 EC50 = 25118.86 nM 4.60
CHEMBL611917 EC50 = 25703.96 nM 4.59
CHEMBL608966 EC50 = 66069.34 nM 4.18