Assay Detail
Functional
CHEMBL640343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of adenosine induced negative inotropic activity against guinea-pig atria (Adenosine A1 receptor)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.02 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61845 | — | — | 1 | 9.25 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 8.88 |
| CHEMBL440115 | FK453 | 1.0 | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61845 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | IC50 | = | 1.31 | nM | 8.88 |
| CHEMBL440115 | FK453 | IC50 | = | 1180.0 | nM | 5.93 |