Assay Detail
Binding
CHEMBL640347
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Binding affinity against Adenosine A1 receptor using N6-[3H]cyclohexyladenosine in guinea pig forebrain membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.45 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368276 | — | — | 1 | 5.54 |
| CHEMBL173327 | — | — | 1 | 5.36 |
| CHEMBL173102 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368276 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL173327 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL173102 | — | Ki | > | 10000.0 | nM | - |