Assay Detail
Binding
CHEMBL640354
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]cyclohexyladenosine binding to guinea pig forebrain membranes Adenosine A1 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.25 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 8.19 |
| CHEMBL157655 | — | — | 1 | 5.92 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.64 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL157655 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL113 | CAFFEINE | Ki | > | 100000.0 | nM | - |