Assay Detail
Binding
CHEMBL640356
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Binding affinity carried out with [3H]cyclohexyladenosine in guinea pig forebrain membranes against adenosine A1 receptor
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.79 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84363 | — | — | 1 | 8.52 |
| CHEMBL318537 | — | — | 1 | 8.26 |
| CHEMBL143567 | — | — | 1 | 8.01 |
| CHEMBL313780 | — | — | 1 | 7.92 |
| CHEMBL320668 | — | — | 1 | 7.89 |
| CHEMBL143622 | — | — | 1 | 7.72 |
| CHEMBL347787 | — | — | 1 | 7.60 |
| CHEMBL142410 | — | — | 1 | 7.31 |
| CHEMBL356458 | — | — | 1 | 7.11 |
| CHEMBL106937 | — | — | 1 | 7.09 |
| CHEMBL339270 | — | — | 1 | 7.00 |
| CHEMBL143565 | — | — | 1 | 6.82 |
| CHEMBL143710 | — | — | 1 | 6.66 |
| CHEMBL342782 | — | — | 1 | 6.60 |
| CHEMBL344992 | — | — | 1 | 6.60 |
| CHEMBL337073 | — | — | 1 | 6.58 |
| CHEMBL141486 | — | — | 1 | 6.40 |
| CHEMBL346382 | — | — | 1 | 6.05 |
| CHEMBL443274 | — | — | 1 | 5.89 |
| CHEMBL102371 | — | — | 1 | 5.80 |
| CHEMBL423016 | — | — | 1 | 5.68 |
| CHEMBL345983 | — | — | 1 | 5.52 |
| CHEMBL102372 | — | — | 1 | 5.13 |
| CHEMBL101800 | — | — | 1 | 4.89 |
| CHEMBL142576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84363 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL318537 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL143567 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL313780 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL320668 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL143622 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL347787 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL142410 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL356458 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL106937 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL339270 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL143565 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL143710 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL342782 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL344992 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL337073 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL141486 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL346382 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL443274 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL102371 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL423016 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL345983 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL102372 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL101800 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL142576 | — | Ki | > | 100000.0 | nM | - |