Assay Detail
Binding
CHEMBL640363
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Displacement of [3H]DPCPX from adenosine A1 receptor of rat brain cortical membrane
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.10 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72287 | — | — | 1 | 6.62 |
| CHEMBL71053 | — | — | 1 | 5.50 |
| CHEMBL305516 | — | — | 1 | 4.19 |
| CHEMBL305975 | — | — | 1 | 4.07 |
| CHEMBL305512 | — | — | 1 | - |
| CHEMBL308087 | — | — | 1 | - |
| CHEMBL72183 | — | — | 1 | - |
| CHEMBL72172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72287 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL71053 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL305516 | — | Ki | = | 64800.0 | nM | 4.19 |
| CHEMBL305975 | — | Ki | = | 84500.0 | nM | 4.07 |
| CHEMBL305512 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL308087 | — | Ki | = | 3870000.0 | nM | - |
| CHEMBL72183 | — | Ki | = | 166000.0 | nM | - |
| CHEMBL72172 | — | Ki | = | 295000.0 | nM | - |