Assay Detail
Binding
CHEMBL640366
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Binding affinity for Adenosine A1 receptor using [3H]- CHA or [3H]- PIA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.70 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610439 | — | — | 1 | 9.66 |
| CHEMBL612176 | — | — | 1 | 9.15 |
| CHEMBL2368675 | — | — | 1 | 9.03 |
| CHEMBL609534 | — | — | 1 | 8.70 |
| CHEMBL1257013 | — | — | 1 | 8.39 |
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 8.34 |
| CHEMBL610386 | — | — | 1 | 8.15 |
| CHEMBL610859 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610439 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL612176 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL2368675 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL609534 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1257013 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL610386 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL610859 | — | Ki | = | 7.1 | nM | 8.15 |