Assay Detail
Binding
CHEMBL640369
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Inhibition of [3H]- (R)-P1A binding to adenosine A1 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.57 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 9.35 |
| CHEMBL284969 | — | — | 1 | 9.22 |
| CHEMBL139000 | (R)-PIA | — | 1 | 8.92 |
| CHEMBL315056 | — | — | 1 | 8.85 |
| CHEMBL610407 | — | — | 1 | 8.12 |
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 7.80 |
| CHEMBL312917 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL284969 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL139000 | (R)-PIA | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL315056 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL610407 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL312917 | — | Ki | = | 20.0 | nM | 7.70 |