Assay Detail
Binding
CHEMBL640417
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Compound was evaluated for the inhibition of binding of [3H]AMPA to the AMPA receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.53 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 7.40 |
| CHEMBL83720 | — | — | 1 | 5.22 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.22 |
| CHEMBL353261 | — | — | 1 | 4.28 |
| CHEMBL315203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL83720 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL275040 | KAINIC ACID | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL353261 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL315203 | — | IC50 | > | 100000.0 | nM | - |