Assay Detail
Binding
CHEMBL640438
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Inhibitory activity was tested against rat ATP-Citrate Lyase (ACL) enzyme
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.06 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119628 | — | — | 3 | 6.16 |
| CHEMBL420700 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119628 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL119628 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL119628 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL420700 | — | Ki | = | 1200.0 | nM | 5.92 |