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Assay Detail

CHEMBL640453

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was tested in vitro for inhibition of human erythrocytic adenosine deaminase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Adenosine deaminase (CHEMBL1910)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+/-)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d] [1,3]diazepin-8-ol and some selected C-5 homologues of pentostatin.
Showalter HD, Putt SR, Borondy PE, Shillis JL.
J Med Chem (1983) 26 : 1478 -1482
PubMed 6604819 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 11.00 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL284483 COFORMYCIN 2.0 1 11.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL284483 COFORMYCIN Ki = 0.01 nM 11.00