Assay Detail
Functional
CHEMBL640537
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Antagonistic affinity against native rat cortex Alpha-2 adrenergic receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.43 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27013 | — | — | 1 | 7.00 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 6.80 |
| CHEMBL29591 | — | — | 1 | 6.23 |
| CHEMBL423294 | CYCLAZOSIN | — | 1 | 6.13 |
| CHEMBL543741 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27013 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2 | PRAZOSIN | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL29591 | — | Ki | = | 588.84 | nM | 6.23 |
| CHEMBL423294 | CYCLAZOSIN | Ki | = | 741.31 | nM | 6.13 |
| CHEMBL543741 | — | Ki | = | 1047.13 | nM | 5.98 |