Assay Detail
Binding
CHEMBL640575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Jurkat |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cyclic AMP-dependent transcription factor ATF-1 (CHEMBL3255) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.02 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336546 | — | — | 1 | 7.30 |
| CHEMBL131636 | — | — | 1 | 6.92 |
| CHEMBL134490 | — | — | 1 | 6.82 |
| CHEMBL135133 | — | — | 1 | 6.31 |
| CHEMBL334485 | — | — | 1 | 6.30 |
| CHEMBL336099 | — | — | 1 | 6.30 |
| CHEMBL423153 | — | — | 1 | 6.18 |
| CHEMBL134603 | — | — | 1 | 6.05 |
| CHEMBL133940 | — | — | 1 | 5.92 |
| CHEMBL337482 | — | — | 1 | 5.92 |
| CHEMBL131789 | — | — | 1 | 5.80 |
| CHEMBL131622 | — | — | 1 | 5.57 |
| CHEMBL134990 | — | — | 1 | 5.55 |
| CHEMBL337695 | — | — | 1 | 5.52 |
| CHEMBL337516 | — | — | 1 | 5.52 |
| CHEMBL131976 | — | — | 1 | 5.52 |
| CHEMBL335697 | — | — | 1 | 5.42 |
| CHEMBL335655 | — | — | 1 | 5.40 |
| CHEMBL134522 | — | — | 1 | - |
| CHEMBL335703 | — | — | 1 | - |
| CHEMBL134876 | — | — | 1 | - |
| CHEMBL134773 | — | — | 1 | - |
| CHEMBL335080 | — | — | 1 | - |
| CHEMBL133159 | — | — | 1 | - |
| CHEMBL134776 | — | — | 1 | - |
| CHEMBL132257 | — | — | 1 | - |
| CHEMBL424086 | — | — | 1 | - |
| CHEMBL131741 | — | — | 1 | - |
| CHEMBL134576 | — | — | 1 | - |
| CHEMBL134863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336546 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL131636 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL134490 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL135133 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL334485 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL336099 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL423153 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL134603 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL133940 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL337482 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL131789 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL131622 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL134990 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL337695 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL131976 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL337516 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL335697 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL335655 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL133044 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL134863 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL134576 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL131741 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL424086 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL132257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL134776 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL133159 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL335080 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL134773 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL134876 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL335703 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL134522 | — | IC50 | > | 10000.0 | nM | - |