Assay Detail
Binding
CHEMBL640694
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Binding affinity for Adenosine A1 receptor from rat cerebral cortex membranes using [3H](R)-PIA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.74 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | — | 1 | 7.68 |
| CHEMBL7266 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL7266 | — | IC50 | = | 1570.0 | nM | 5.80 |