Assay Detail
Binding
CHEMBL640696
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Binding affinity to adenosine A1 receptor of rat brain membranes with 1 M NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.44 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355370 | — | — | 1 | 8.52 |
| CHEMBL351481 | — | — | 1 | 8.47 |
| CHEMBL349519 | — | — | 1 | 8.47 |
| CHEMBL163574 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355370 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL351481 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL349519 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL163574 | — | IC50 | = | 5.2 | nM | 8.28 |