Assay Detail
Binding
CHEMBL640780
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Affinity for adenosine A1 receptor at rat cortical receptors using 1 nM [3H]PIA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.52 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 8.46 |
| CHEMBL2113406 | — | — | 1 | 8.12 |
| CHEMBL2113484 | — | — | 1 | 7.92 |
| CHEMBL604406 | — | — | 1 | 7.31 |
| CHEMBL2364548 | — | — | 1 | 7.13 |
| CHEMBL2113577 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL2113406 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL2113484 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL604406 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL2364548 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL2113577 | — | Ki | = | 712.0 | nM | 6.15 |