Assay Detail
Binding
CHEMBL640783
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Affinity for Adenosine A1 receptor determined by [3H]N6-cyclohexyladenosine binding to rat brain membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High selectivity of novel isoguanosine analogues for the adenosine A1 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.48 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 9.22 |
| CHEMBL45891 | — | — | 1 | 8.89 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 7.89 |
| CHEMBL608168 | — | — | 1 | 7.72 |
| CHEMBL607881 | — | — | 1 | 7.70 |
| CHEMBL608742 | — | — | 1 | 7.46 |
| CHEMBL608747 | — | — | 1 | 7.40 |
| CHEMBL608445 | — | — | 1 | 7.26 |
| CHEMBL607606 | — | — | 1 | 7.16 |
| CHEMBL1688963 | ISOGUANOSINE | — | 1 | 7.03 |
| CHEMBL608748 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL45891 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL477 | ADENOSINE | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL608168 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL607881 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL608742 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL608747 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL608445 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL607606 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL1688963 | ISOGUANOSINE | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL608748 | — | Ki | = | 30000.0 | nM | 4.52 |