Assay Detail
Binding
CHEMBL640785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]CHA (N6-cyclohexyl adenosine) to rat brain membrane Adenosine A1 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.26 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 9.52 |
| CHEMBL139000 | (R)-PIA | — | 1 | 9.22 |
| CHEMBL2113388 | — | — | 1 | 8.33 |
| CHEMBL400189 | — | — | 1 | 8.02 |
| CHEMBL420705 | (S)-PIA | — | 1 | 7.96 |
| CHEMBL3143982 | — | — | 1 | 7.64 |
| CHEMBL603977 | — | — | 1 | 7.30 |
| CHEMBL3143985 | — | — | 1 | 7.00 |
| CHEMBL3143983 | — | — | 1 | 6.57 |
| CHEMBL73809 | — | — | 1 | 6.13 |
| CHEMBL3143984 | — | — | 1 | 5.11 |
| CHEMBL480143 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL139000 | (R)-PIA | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2113388 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL400189 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL420705 | (S)-PIA | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3143982 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL603977 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3143985 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3143983 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL73809 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL3143984 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL480143 | — | Ki | = | 51000.0 | nM | 4.29 |