Assay Detail
Binding
CHEMBL641001
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Inhibition of photolabeling of 34 kDa polypeptide in adenosine A1 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.85 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351481 | — | — | 1 | 7.80 |
| CHEMBL605469 | — | — | 1 | 6.37 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 4.96 |
| CHEMBL464859 | NECA | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351481 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL605469 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL464859 | NECA | IC50 | = | 52000.0 | nM | 4.28 |