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Assay Detail

CHEMBL641008

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Hamster Liver mitochondrial ALDH-2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cricetulus griseus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Aldehyde dehydrogenase, mitochondrial (CHEMBL1935)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin.
Rooke N, Li DJ, Li J, Keung WM.
J Med Chem (2000) 43 : 4169 -4179
PubMed 11063613 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.09 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL113123 1 8.52
CHEMBL112696 1 8.40
CHEMBL112007 1 8.05
CHEMBL113640 1 8.05
CHEMBL486422 DAIDZIN 1 7.40
CHEMBL115092 1 7.40
CHEMBL115314 1 6.58
CHEMBL113617 1 6.57
CHEMBL112437 1 6.52
CHEMBL134275 1 6.40
CHEMBL112165 1 6.10
CHEMBL8145 DAIDZEIN 2.0 1 5.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL113123 IC50 = 3.0 nM 8.52
CHEMBL112696 IC50 = 4.0 nM 8.40
CHEMBL112007 IC50 = 9.0 nM 8.05
CHEMBL113640 IC50 = 9.0 nM 8.05
CHEMBL486422 DAIDZIN IC50 = 40.0 nM 7.40
CHEMBL115092 IC50 = 40.0 nM 7.40
CHEMBL115314 IC50 = 260.0 nM 6.58
CHEMBL113617 IC50 = 270.0 nM 6.57
CHEMBL112437 IC50 = 300.0 nM 6.52
CHEMBL134275 IC50 = 400.0 nM 6.40
CHEMBL112165 IC50 = 800.0 nM 6.10
CHEMBL8145 DAIDZEIN IC50 = 9000.0 nM 5.05