Assay Detail
Binding
CHEMBL641037
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Binding of 1 nM [3H]CHA to Adenosine A1 receptor of rat cerebral cortical membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.47 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26350 | — | — | 1 | 6.30 |
| CHEMBL157655 | — | — | 1 | 6.16 |
| CHEMBL416013 | — | — | 1 | 5.48 |
| CHEMBL1250 | 1-METHYLXANTHINE | — | 1 | 5.05 |
| CHEMBL286785 | — | — | 1 | 5.00 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26350 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL157655 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL416013 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL1250 | 1-METHYLXANTHINE | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL286785 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 14000.0 | nM | 4.85 |