Assay Detail
Functional
CHEMBL641048
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Evaluated for its postsynaptic Alpha-2 adrenergic receptor antagonist activity against dog saphenous vein using norepinephrine as the control expressed as slope
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Saphenous vein |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of ABT-200: a putative novel antidepressant combining potent -2 antagonism with moderate NE uptake inhibition
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.64 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27926 | NAPITANE | 2.0 | 3 | 8.25 |
| CHEMBL25014 | — | — | 1 | 8.15 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 7.28 |
| CHEMBL285367 | — | — | 1 | 6.80 |
| CHEMBL433033 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27926 | NAPITANE | Kd | = | 5.623 | nM | 8.25 |
| CHEMBL27926 | NAPITANE | Kd | = | 6.761 | nM | 8.17 |
| CHEMBL27926 | NAPITANE | Kd | = | 7.079 | nM | 8.15 |
| CHEMBL25014 | — | Kd | = | 7.079 | nM | 8.15 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 52.48 | nM | 7.28 |
| CHEMBL285367 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL433033 | — | Kd | = | 208.93 | nM | 6.68 |