Assay Detail
Binding
CHEMBL641069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-CCPA from adenosine A1 receptor of rat brain cortical membrane preparations
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.83 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412854 | — | — | 1 | 8.59 |
| CHEMBL8865 | — | — | 1 | 8.57 |
| CHEMBL8732 | — | — | 1 | 8.44 |
| CHEMBL266099 | — | — | 1 | 8.36 |
| CHEMBL8810 | — | — | 1 | 8.24 |
| CHEMBL417601 | — | — | 1 | 8.20 |
| CHEMBL8495 | — | — | 1 | 8.19 |
| CHEMBL9030 | — | — | 1 | 8.11 |
| CHEMBL267474 | — | — | 1 | 7.75 |
| CHEMBL9034 | — | — | 1 | 7.68 |
| CHEMBL8789 | — | — | 1 | 7.40 |
| CHEMBL268617 | — | — | 1 | 6.32 |
| CHEMBL8565 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412854 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL8865 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL8732 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL266099 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL8810 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL417601 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL8495 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL9030 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL267474 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL9034 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL8789 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL268617 | — | Ki | = | 475.0 | nM | 6.32 |
| CHEMBL8565 | — | Ki | = | 1238.0 | nM | 5.91 |