Assay Detail
Binding
CHEMBL641070
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Binding affinity for adenosine A1 receptor using [3H]PIA in rat brain cortical membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.57 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158507 | — | — | 1 | 8.00 |
| CHEMBL274855 | — | — | 1 | 7.17 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 7.05 |
| CHEMBL418333 | — | — | 1 | 6.68 |
| CHEMBL9069 | — | — | 1 | 6.58 |
| CHEMBL275987 | — | — | 1 | 5.66 |
| CHEMBL8488 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158507 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL274855 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL418333 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL9069 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL275987 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL8488 | — | Ki | = | 14000.0 | nM | 4.85 |