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Assay Detail

CHEMBL641136

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human alcohol dehydrogenase pi activity
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

All-trans-retinol dehydrogenase [NAD(+)] ADH4 (CHEMBL2990)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of human alcohol dehydrogenases by formamides.
Schindler JF, Berst KB, Plapp BV.
J Med Chem (1998) 41 : 1696 -1701
PubMed 9572895 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 4.52 5.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291214 1 5.15
CHEMBL43719 HEPTYLFORMAMIDE 1 4.96
CHEMBL46655 1 4.51
CHEMBL48122 1 4.40
CHEMBL46778 CYCLOHEXYLFORMAMIDE 1 4.08
CHEMBL45704 1 4.02
CHEMBL45705 1 -
CHEMBL300291 1 -
CHEMBL299094 1 -
CHEMBL49963 1 -
CHEMBL295789 1 -
CHEMBL46293 1 -
CHEMBL297125 1 -
CHEMBL45466 1 -
CHEMBL297216 1 -
CHEMBL44630 1 -
CHEMBL296027 1 -
CHEMBL45844 CYCLOBUTYL(CYCLOPENTYL)FORMAMIDE 1 -
CHEMBL49774 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291214 Ki = 7100.0 nM 5.15
CHEMBL43719 HEPTYLFORMAMIDE Ki = 11000.0 nM 4.96
CHEMBL46655 Ki = 31000.0 nM 4.51
CHEMBL48122 Ki = 40000.0 nM 4.40
CHEMBL46778 CYCLOHEXYLFORMAMIDE Ki = 84000.0 nM 4.08
CHEMBL45704 Ki = 96000.0 nM 4.02
CHEMBL45705 Ki = 120000.0 nM -
CHEMBL300291 Ki = 191000.0 nM -
CHEMBL299094 Ki = 340000.0 nM -
CHEMBL49963 Ki = 5200000.0 nM -
CHEMBL295789 Ki = 150000.0 nM -
CHEMBL46293 Ki = 110000.0 nM -
CHEMBL297125 Ki = 280000.0 nM -
CHEMBL45466 Ki = 110000.0 nM -
CHEMBL297216 Ki = 300000.0 nM -
CHEMBL44630 Ki = 150000.0 nM -
CHEMBL296027 Ki = 1900000.0 nM -
CHEMBL45844 CYCLOBUTYL(CYCLOPENTYL)FORMAMIDE Ki = 360000.0 nM -
CHEMBL49774 Ki = 450000.0 nM -