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Compound Detail

CHEMBL46778

CYCLOHEXYLFORMAMIDE
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Basic Information

ChEMBL ID CHEMBL46778
Name CYCLOHEXYLFORMAMIDE
Phase Preclinical
Structure Type MOL
InChI Key SWGXDLRCJNEEGZ-UHFFFAOYSA-N
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

127.2
MW (Da)
1.07
ALogP
1
HBA
1
HBD
29.1
PSA (Ų)
0.55
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C7H13NO
MW 127.19
Aromatic Rings 0
Heavy Atoms 9
NP-Likeness 0.33

Activity Summary

Ki 6 meas. best 5.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alcohol dehydrogenase 1A
CHEMBL1970
Ki 5.64 5.64 2300.0 1
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
CHEMBL3284
Ki 5.47 5.47 3400.0 1
Alcohol dehydrogenase 1C
CHEMBL3285
Ki 5.28 5.28 5200.0 1
Alcohol dehydrogenase
CHEMBL2111372
Ki 5.06 5.06 8700.0 1
All-trans-retinol dehydrogenase [NAD(+)] ADH4
CHEMBL2990
Ki 4.08 4.08 84000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9572895 10.1021/jm9707380 Alcohol dehydrogenase 1
9572895 10.1021/jm9707380 Alcohol dehydrogenase 1A 1
9572895 10.1021/jm9707380 All-trans-retinol dehydrogenase [NAD(+)] ADH1B 1
9572895 10.1021/jm9707380 Alcohol dehydrogenase 1C 1
9572895 10.1021/jm9707380 All-trans-retinol dehydrogenase [NAD(+)] ADH4 1
9572895 10.1021/jm9707380 All-trans-retinol dehydrogenase [NAD(+)] ADH7 1

Data from ChEMBL 36 via Core Engine