Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL641141

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of hamster liver aldehyde dehydrogenase ALDH-2
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cricetulus griseus
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Aldehyde dehydrogenase, mitochondrial (CHEMBL1935)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.
Gao GY, Li DJ, Keung WM.
J Med Chem (2001) 44 : 3320 -3328
PubMed 11563931 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 6.47 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL113123 1 7.40
CHEMBL114397 1 7.40
CHEMBL114083 1 7.40
CHEMBL112007 1 7.30
CHEMBL112696 1 7.30
CHEMBL113640 1 7.22
CHEMBL113113 1 7.16
CHEMBL115109 1 7.10
CHEMBL115092 1 7.10
CHEMBL486422 DAIDZIN 1 7.10
CHEMBL113586 1 7.00
CHEMBL109641 1 7.00
CHEMBL113058 1 6.92
CHEMBL262662 1 6.89
CHEMBL326803 1 6.89
CHEMBL111984 1 6.82
CHEMBL109649 1 6.82
CHEMBL112165 1 6.75
CHEMBL112865 1 6.62
CHEMBL109868 1 6.60
CHEMBL115314 1 6.58
CHEMBL113617 1 6.57
CHEMBL112070 1 6.55
CHEMBL112437 1 6.52
CHEMBL326236 1 6.50
CHEMBL111989 1 6.16
CHEMBL324628 1 6.00
CHEMBL419936 1 5.92
CHEMBL325841 1 5.82
CHEMBL110472 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL113123 IC50 = 40.0 nM 7.40
CHEMBL114083 IC50 = 40.0 nM 7.40
CHEMBL114397 IC50 = 40.0 nM 7.40
CHEMBL112007 IC50 = 50.0 nM 7.30
CHEMBL112696 IC50 = 50.0 nM 7.30
CHEMBL113640 IC50 = 60.0 nM 7.22
CHEMBL113113 IC50 = 70.0 nM 7.16
CHEMBL115109 IC50 = 80.0 nM 7.10
CHEMBL115092 IC50 = 80.0 nM 7.10
CHEMBL486422 DAIDZIN IC50 = 80.0 nM 7.10
CHEMBL113586 IC50 = 100.0 nM 7.00
CHEMBL109641 IC50 = 100.0 nM 7.00
CHEMBL113058 IC50 = 120.0 nM 6.92
CHEMBL262662 IC50 = 130.0 nM 6.89
CHEMBL326803 IC50 = 130.0 nM 6.89
CHEMBL111984 IC50 = 150.0 nM 6.82
CHEMBL109649 IC50 = 150.0 nM 6.82
CHEMBL112165 IC50 = 180.0 nM 6.75
CHEMBL112865 IC50 = 240.0 nM 6.62
CHEMBL109868 IC50 = 250.0 nM 6.60
CHEMBL115314 IC50 = 260.0 nM 6.58
CHEMBL113617 IC50 = 270.0 nM 6.57
CHEMBL112070 IC50 = 280.0 nM 6.55
CHEMBL112437 IC50 = 300.0 nM 6.52
CHEMBL326236 IC50 = 320.0 nM 6.50
CHEMBL111989 IC50 = 700.0 nM 6.16
CHEMBL324628 IC50 = 1000.0 nM 6.00
CHEMBL419936 IC50 = 1200.0 nM 5.92
CHEMBL325841 IC50 = 1500.0 nM 5.82
CHEMBL110472 IC50 = 1500.0 nM 5.82
CHEMBL109925 IC50 = 1500.0 nM 5.82
CHEMBL115161 IC50 = 1700.0 nM 5.77
CHEMBL326965 IC50 = 2000.0 nM 5.70
CHEMBL112286 IC50 = 2500.0 nM 5.60
CHEMBL110038 IC50 = 3500.0 nM 5.46
CHEMBL112259 IC50 = 4500.0 nM 5.35
CHEMBL276473 4'-HYDROXYCHALCONE IC50 = 7000.0 nM 5.16
CHEMBL113855 IC50 = 7200.0 nM 5.14
CHEMBL8145 DAIDZEIN IC50 = 9000.0 nM 5.05
CHEMBL113616 IC50 > 9000.0 nM -
CHEMBL113744 IC50 > 9000.0 nM -
CHEMBL420490 IC50 >> 9000.0 nM -
CHEMBL465980 ONONIN IC50 > 6000.0 nM -