Assay Detail
Binding
CHEMBL641229
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In vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblasts
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.81 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117248 | — | — | 1 | 6.66 |
| CHEMBL118055 | — | — | 1 | 6.05 |
| CHEMBL318544 | — | — | 1 | 5.77 |
| CHEMBL13789 | — | — | 1 | 5.62 |
| CHEMBL325745 | — | — | 1 | 5.52 |
| CHEMBL116700 | — | — | 1 | 5.23 |
| CHEMBL117914 | — | — | 1 | - |
| CHEMBL326837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117248 | — | IC50 | = | 218.78 | nM | 6.66 |
| CHEMBL118055 | — | IC50 | = | 891.25 | nM | 6.05 |
| CHEMBL318544 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL13789 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL325745 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL116700 | — | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL117914 | — | IC50 | < | 30199.52 | nM | - |
| CHEMBL326837 | — | IC50 | < | 30199.52 | nM | - |