Assay Detail
Binding
CHEMBL641238
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Inhibition acetylcholinesterase (AChE) enzyme.
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 5.81 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140020 | — | — | 1 | 8.10 |
| CHEMBL136526 | — | — | 1 | 7.47 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.24 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.12 |
| CHEMBL54126 | NEOSTIGMINE BROMIDE | 2.0 | 1 | 7.04 |
| CHEMBL609150 | — | — | 1 | 6.96 |
| CHEMBL609671 | — | — | 1 | 6.82 |
| CHEMBL54727 | — | — | 1 | 6.46 |
| CHEMBL612100 | — | — | 1 | 6.34 |
| CHEMBL139330 | — | — | 1 | 6.18 |
| CHEMBL60745 | EDROPHONIUM BROMIDE | — | 1 | 6.11 |
| CHEMBL422459 | — | — | 1 | 6.01 |
| CHEMBL609149 | — | — | 1 | 6.01 |
| CHEMBL609668 | — | — | 1 | 5.77 |
| CHEMBL609409 | — | — | 1 | 5.75 |
| CHEMBL137561 | — | — | 1 | 5.55 |
| CHEMBL343344 | — | — | 1 | 5.52 |
| CHEMBL137560 | — | — | 1 | 5.51 |
| CHEMBL138072 | — | — | 1 | 5.42 |
| CHEMBL338492 | — | — | 1 | 5.27 |
| CHEMBL136294 | — | — | 1 | 5.22 |
| CHEMBL612099 | — | — | 1 | 5.20 |
| CHEMBL609672 | — | — | 1 | 4.46 |
| CHEMBL612098 | — | — | 1 | 4.40 |
| CHEMBL136719 | — | — | 1 | 4.39 |
| CHEMBL136669 | — | — | 1 | 4.16 |
| CHEMBL136916 | — | — | 1 | 4.07 |
| CHEMBL139684 | — | — | 1 | 4.06 |
| CHEMBL136870 | — | — | 1 | - |
| CHEMBL140403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140020 | — | IC50 | = | 7.998 | nM | 8.10 |
| CHEMBL136526 | — | IC50 | = | 33.96 | nM | 7.47 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 57.02 | nM | 7.24 |
| CHEMBL95 | TACRINE | IC50 | = | 76.03 | nM | 7.12 |
| CHEMBL54126 | NEOSTIGMINE BROMIDE | IC50 | = | 90.99 | nM | 7.04 |
| CHEMBL609150 | — | IC50 | = | 109.9 | nM | 6.96 |
| CHEMBL609671 | — | IC50 | = | 152.05 | nM | 6.82 |
| CHEMBL54727 | — | IC50 | = | 349.95 | nM | 6.46 |
| CHEMBL612100 | — | IC50 | = | 460.26 | nM | 6.34 |
| CHEMBL139330 | — | IC50 | = | 659.17 | nM | 6.18 |
| CHEMBL60745 | EDROPHONIUM BROMIDE | IC50 | = | 779.83 | nM | 6.11 |
| CHEMBL422459 | — | IC50 | = | 972.75 | nM | 6.01 |
| CHEMBL609149 | — | IC50 | = | 970.51 | nM | 6.01 |
| CHEMBL609668 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL609409 | — | IC50 | = | 1798.87 | nM | 5.75 |
| CHEMBL137561 | — | IC50 | = | 2824.88 | nM | 5.55 |
| CHEMBL343344 | — | IC50 | = | 3013.01 | nM | 5.52 |
| CHEMBL137560 | — | IC50 | = | 3111.72 | nM | 5.51 |
| CHEMBL138072 | — | IC50 | = | 3767.04 | nM | 5.42 |
| CHEMBL338492 | — | IC50 | = | 5333.35 | nM | 5.27 |
| CHEMBL136294 | — | IC50 | = | 5970.35 | nM | 5.22 |
| CHEMBL612099 | — | IC50 | = | 6295.06 | nM | 5.20 |
| CHEMBL609672 | — | IC50 | = | 34994.52 | nM | 4.46 |
| CHEMBL612098 | — | IC50 | = | 39994.47 | nM | 4.40 |
| CHEMBL136719 | — | IC50 | = | 40831.94 | nM | 4.39 |
| CHEMBL136669 | — | IC50 | = | 69023.98 | nM | 4.16 |
| CHEMBL136916 | — | IC50 | = | 84722.74 | nM | 4.07 |
| CHEMBL139684 | — | IC50 | = | 87902.25 | nM | 4.06 |
| CHEMBL335108 | — | IC50 | = | 238781.13 | nM | - |
| CHEMBL139908 | — | IC50 | = | 125892.54 | nM | - |
| CHEMBL920 | CHOLINE | IC50 | = | 3013006.02 | nM | - |
| CHEMBL136568 | — | IC50 | = | 1510080.15 | nM | - |
| CHEMBL343319 | — | IC50 | = | 141253.75 | nM | - |
| CHEMBL423352 | — | IC50 | = | 3706807.22 | nM | - |
| CHEMBL138988 | — | IC50 | = | 122461.62 | nM | - |
| CHEMBL334938 | — | IC50 | = | 11587773.56 | nM | - |
| CHEMBL1626784 | — | IC50 | = | 191866.87 | nM | - |
| CHEMBL609718 | — | IC50 | = | 628058.36 | nM | - |
| CHEMBL139259 | — | IC50 | = | 690239.8 | nM | - |
| CHEMBL344924 | — | IC50 | = | 597035.29 | nM | - |
| CHEMBL341956 | — | IC50 | = | 2387811.28 | nM | - |
| CHEMBL344864 | — | IC50 | = | 3828247.43 | nM | - |
| CHEMBL335439 | — | IC50 | = | 8128305.16 | nM | - |
| CHEMBL136148 | — | IC50 | = | 597035.29 | nM | - |
| CHEMBL609719 | — | IC50 | = | 5116818.36 | nM | - |
| CHEMBL345031 | — | IC50 | = | 1761976.05 | nM | - |
| CHEMBL337142 | — | IC50 | = | 470977.33 | nM | - |
| CHEMBL135503 | — | IC50 | = | 2917427.01 | nM | - |
| CHEMBL140403 | — | IC50 | = | 1129795.91 | nM | - |
| CHEMBL136870 | — | IC50 | = | 345143.74 | nM | - |