Assay Detail
Functional
CHEMBL641369
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Antagonistic activity against clonidine-stimulated rat vas deferens presynaptic alpha-2 adrenergic receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 7.09 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 7.90 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.65 |
| CHEMBL280514 | — | — | 1 | 7.40 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.27 |
| CHEMBL18194 | — | — | 1 | 6.80 |
| CHEMBL18094 | — | — | 1 | 6.40 |
| CHEMBL17605 | — | — | 1 | 6.20 |
| CHEMBL18306 | — | — | 1 | - |
| CHEMBL17223 | — | — | 1 | - |
| CHEMBL17648 | — | — | 1 | - |
| CHEMBL17926 | — | — | 1 | - |
| CHEMBL18270 | — | — | 1 | - |
| CHEMBL278934 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10347 | RAUWOLSCINE | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 22.39 | nM | 7.65 |
| CHEMBL280514 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL6437 | MIANSERIN | Kd | = | 53.7 | nM | 7.27 |
| CHEMBL18194 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL18094 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL17605 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL18306 | — | Kd | > | 1584.89 | nM | - |
| CHEMBL17223 | — | Kd | > | 1584.89 | nM | - |
| CHEMBL17648 | — | Kd | > | 1584.89 | nM | - |
| CHEMBL17926 | — | Kd | > | 1258.93 | nM | - |
| CHEMBL18270 | — | Kd | > | 1584.89 | nM | - |
| CHEMBL278934 | — | Kd | > | 1995.26 | nM | - |