Assay Detail
Binding
CHEMBL641431
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Binding affinity for adenosine A3 receptor in CHO cell membranes using [125I]IB-MECA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.48 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 6.38 |
| CHEMBL2113492 | — | — | 1 | 5.25 |
| CHEMBL2113489 | — | — | 1 | 4.82 |
| CHEMBL1791423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL2113492 | — | Ki | = | 5560.0 | nM | 5.25 |
| CHEMBL2113489 | — | Ki | = | 15100.0 | nM | 4.82 |
| CHEMBL1791423 | — | Ki | = | 310000.0 | nM | - |