Assay Detail
Functional
CHEMBL641435
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Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.83 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17123 | — | — | 1 | 5.56 |
| CHEMBL16997 | — | — | 1 | 4.82 |
| CHEMBL27041 | — | — | 1 | 4.12 |
| CHEMBL16724 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17123 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL16997 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL27041 | — | Ki | = | 75700.0 | nM | 4.12 |
| CHEMBL16724 | — | Ki | = | 173000.0 | nM | - |