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Assay Detail

CHEMBL641506

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Binding
Inhibition of human acetylcholinesterase-I
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Sowell JW, Tang Y, Valli MJ, Chapman JM, Usher LA, Vaughan CM, Kosh JW.
J Med Chem (1992) 35 : 1102 -1108
PubMed 1552502 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.93 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL12781 1 6.75
CHEMBL95 TACRINE 4.0 1 6.75
CHEMBL12937 1 6.68
CHEMBL12472 1 6.58
CHEMBL12858 1 6.54
CHEMBL275537 1 6.48
CHEMBL13308 1 6.30
CHEMBL268499 1 6.13
CHEMBL13166 1 6.05
CHEMBL12473 1 5.82
CHEMBL12941 1 5.60
CHEMBL1202417 1 5.52
CHEMBL267649 1 5.05
CHEMBL13522 1 4.36
CHEMBL13214 1 4.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL12781 IC50 = 180.0 nM 6.75
CHEMBL95 TACRINE IC50 = 180.0 nM 6.75
CHEMBL12937 IC50 = 210.0 nM 6.68
CHEMBL12472 IC50 = 260.0 nM 6.58
CHEMBL12858 IC50 = 290.0 nM 6.54
CHEMBL275537 IC50 = 330.0 nM 6.48
CHEMBL13308 IC50 = 500.0 nM 6.30
CHEMBL268499 IC50 = 740.0 nM 6.13
CHEMBL13166 IC50 = 900.0 nM 6.05
CHEMBL12473 IC50 = 1500.0 nM 5.82
CHEMBL12941 IC50 = 2500.0 nM 5.60
CHEMBL1202417 IC50 = 3000.0 nM 5.52
CHEMBL267649 IC50 = 9000.0 nM 5.05
CHEMBL13522 IC50 = 44000.0 nM 4.36
CHEMBL13214 IC50 = 48000.0 nM 4.32