Assay Detail
Functional
CHEMBL641536
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Antagonistic activity against Alpha-2 adrenergic receptor in the prostatic portion of the rat vas deferens
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 20 | 6.63 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.03 |
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 7.92 |
| CHEMBL543467 | IDAZOXAN HYDROCHLORIDE | — | 1 | 7.80 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.71 |
| CHEMBL31836 | PIPEROXAN | 2.0 | 1 | 7.40 |
| CHEMBL1204368 | — | — | 1 | 7.00 |
| CHEMBL1203734 | — | — | 1 | 6.84 |
| CHEMBL1203727 | — | — | 1 | 6.84 |
| CHEMBL578481 | IMILOXAN HYDROCHLORIDE | -1.0 | 1 | 6.71 |
| CHEMBL1203725 | — | — | 1 | 6.70 |
| CHEMBL1203738 | — | — | 1 | 6.58 |
| CHEMBL1203739 | — | — | 1 | 6.57 |
| CHEMBL1203715 | — | — | 1 | 6.21 |
| CHEMBL1203742 | — | — | 1 | 6.20 |
| CHEMBL1237158 | — | — | 1 | 6.10 |
| CHEMBL434858 | — | — | 1 | 6.00 |
| CHEMBL1237152 | — | — | 1 | 5.60 |
| CHEMBL1203729 | — | — | 1 | 5.51 |
| CHEMBL162087 | — | — | 1 | 5.50 |
| CHEMBL1203743 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Kd | = | 9.333 | nM | 8.03 |
| CHEMBL10347 | RAUWOLSCINE | Kd | = | 12.02 | nM | 7.92 |
| CHEMBL543467 | IDAZOXAN HYDROCHLORIDE | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 19.5 | nM | 7.71 |
| CHEMBL31836 | PIPEROXAN | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL1204368 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL1203734 | — | Kd | = | 144.54 | nM | 6.84 |
| CHEMBL1203727 | — | Kd | = | 144.54 | nM | 6.84 |
| CHEMBL578481 | IMILOXAN HYDROCHLORIDE | Kd | = | 194.98 | nM | 6.71 |
| CHEMBL1203725 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL1203738 | — | Kd | = | 263.03 | nM | 6.58 |
| CHEMBL1203739 | — | Kd | = | 269.15 | nM | 6.57 |
| CHEMBL1203715 | — | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL1203742 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL1237158 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL434858 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL1237152 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL1203729 | — | Kd | = | 3090.3 | nM | 5.51 |
| CHEMBL162087 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL1203743 | — | Kd | = | 3981.07 | nM | 5.40 |