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Assay Detail

CHEMBL641564

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration in vitro and ex vivo for anti-AChE activity in rat brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Brain
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL3199)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds
Sugimoto H, Iimura Y, Yamanishi Y, Yamatsu K
Bioorg Med Chem Lett (1992) 2 : 871 -876
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 8.17 9.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94 PHYSOSTIGMINE 3.0 1 9.17
CHEMBL502 DONEPEZIL 4.0 1 8.24
CHEMBL95 TACRINE 4.0 1 7.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94 PHYSOSTIGMINE IC50 = 0.68 nM 9.17
CHEMBL502 DONEPEZIL IC50 = 5.7 nM 8.24
CHEMBL95 TACRINE IC50 = 80.6 nM 7.09