Assay Detail
Binding
CHEMBL641565
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Inhibitory potency against acetylcholinesterase (AChE) of rat cortex homogenate with ethopropazine as BChE inhibitor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.40 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32823 | — | — | 1 | 8.82 |
| CHEMBL76658 | — | — | 1 | 8.06 |
| CHEMBL77374 | — | — | 1 | 7.58 |
| CHEMBL74607 | — | — | 1 | 7.44 |
| CHEMBL1202834 | — | — | 1 | 7.43 |
| CHEMBL1202835 | — | — | 1 | 7.37 |
| CHEMBL1202836 | — | — | 1 | 7.28 |
| CHEMBL76659 | — | — | 1 | 6.95 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 6.94 |
| CHEMBL1202837 | — | — | 1 | 6.91 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32823 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL76658 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL77374 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL74607 | — | IC50 | = | 36.3 | nM | 7.44 |
| CHEMBL1202834 | — | IC50 | = | 37.1 | nM | 7.43 |
| CHEMBL1202835 | — | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL1202836 | — | IC50 | = | 53.1 | nM | 7.28 |
| CHEMBL76659 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL1202837 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL95 | TACRINE | IC50 | = | 223.0 | nM | 6.65 |