Assay Detail
Binding
CHEMBL641566
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Inhibition of acetylcholinesterase (AChE)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 6.72 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311017 | — | — | 1 | 8.00 |
| CHEMBL308793 | — | — | 1 | 7.96 |
| CHEMBL308807 | — | — | 1 | 7.80 |
| CHEMBL75110 | — | — | 1 | 7.70 |
| CHEMBL74560 | — | — | 1 | 7.66 |
| CHEMBL305739 | — | — | 1 | 7.62 |
| CHEMBL74922 | — | — | 1 | 7.54 |
| CHEMBL76470 | — | — | 1 | 7.44 |
| CHEMBL73974 | — | — | 1 | 7.37 |
| CHEMBL73339 | — | — | 1 | 7.33 |
| CHEMBL306179 | — | — | 1 | 7.30 |
| CHEMBL73593 | — | — | 1 | 7.27 |
| CHEMBL74522 | — | — | 1 | 7.27 |
| CHEMBL74809 | — | — | 1 | 7.23 |
| CHEMBL310918 | — | — | 1 | 7.19 |
| CHEMBL73637 | — | — | 1 | 7.17 |
| CHEMBL306175 | — | — | 1 | 7.12 |
| CHEMBL74747 | — | — | 1 | 7.09 |
| CHEMBL74832 | — | — | 1 | 7.05 |
| CHEMBL75013 | ZANAPEZIL | 2.0 | 1 | 7.01 |
| CHEMBL74359 | — | — | 1 | 6.95 |
| CHEMBL74698 | — | — | 1 | 6.90 |
| CHEMBL75157 | — | — | 1 | 6.90 |
| CHEMBL308093 | — | — | 1 | 6.84 |
| CHEMBL414397 | — | — | 1 | 6.79 |
| CHEMBL74340 | — | — | 1 | 6.65 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.57 |
| CHEMBL420378 | — | — | 1 | 6.48 |
| CHEMBL75127 | — | — | 1 | 6.48 |
| CHEMBL310467 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311017 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL308793 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL308807 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL75110 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL74560 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL305739 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL74922 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL76470 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL73974 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL73339 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL306179 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL74522 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL73593 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL74809 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL310918 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL73637 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL306175 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL74747 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL74832 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL75013 | ZANAPEZIL | IC50 | = | 97.7 | nM | 7.01 |
| CHEMBL74359 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL74698 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL75157 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL308093 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL414397 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL74340 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL95 | TACRINE | IC50 | = | 270.9 | nM | 6.57 |
| CHEMBL420378 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL75127 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL310467 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL307832 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL76384 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL306776 | — | IC50 | = | 812.0 | nM | 6.09 |
| CHEMBL72967 | — | IC50 | = | 847.0 | nM | 6.07 |
| CHEMBL307693 | — | IC50 | = | 853.0 | nM | 6.07 |
| CHEMBL307513 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL444841 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL309173 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL73447 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL74962 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL75649 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL76108 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL74533 | — | IC50 | = | 55200.0 | nM | 4.26 |