Assay Detail
Binding
CHEMBL641567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition concentration against rat acetylcholinesterase
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 6.61 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106739 | — | — | 1 | 9.42 |
| CHEMBL107316 | — | — | 1 | 8.28 |
| CHEMBL110268 | — | — | 1 | 8.22 |
| CHEMBL108726 | — | — | 1 | 8.11 |
| CHEMBL322392 | — | — | 1 | 8.00 |
| CHEMBL311017 | — | — | 1 | 8.00 |
| CHEMBL308793 | — | — | 1 | 7.96 |
| CHEMBL105874 | — | — | 1 | 7.89 |
| CHEMBL75110 | — | — | 1 | 7.70 |
| CHEMBL107572 | — | — | 1 | 7.70 |
| CHEMBL74560 | — | — | 1 | 7.66 |
| CHEMBL319003 | — | — | 1 | 7.62 |
| CHEMBL320636 | — | — | 1 | 7.62 |
| CHEMBL110627 | — | — | 1 | 7.55 |
| CHEMBL106891 | — | — | 1 | 7.52 |
| CHEMBL108369 | — | — | 1 | 7.35 |
| CHEMBL110554 | — | — | 1 | 7.30 |
| CHEMBL108632 | — | — | 1 | 7.28 |
| CHEMBL73637 | — | — | 1 | 7.17 |
| CHEMBL107208 | — | — | 1 | 7.12 |
| CHEMBL74747 | — | — | 1 | 7.09 |
| CHEMBL75013 | ZANAPEZIL | 2.0 | 1 | 7.01 |
| CHEMBL418807 | — | — | 1 | 7.00 |
| CHEMBL322393 | — | — | 1 | 6.82 |
| CHEMBL110244 | — | — | 1 | 6.79 |
| CHEMBL107263 | — | — | 1 | 6.66 |
| CHEMBL105825 | — | — | 1 | 6.60 |
| CHEMBL322328 | — | — | 1 | 6.57 |
| CHEMBL107110 | — | — | 1 | 6.56 |
| CHEMBL106574 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106739 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL107316 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL110268 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL108726 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL322392 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL311017 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL308793 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL105874 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL75110 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL107572 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL74560 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL319003 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL320636 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL110627 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL106891 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL108369 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL110554 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL108632 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL73637 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL107208 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL74747 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL75013 | ZANAPEZIL | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL418807 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL322393 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL110244 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL107263 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL105825 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL322328 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL107110 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL106574 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL310467 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL320730 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL105932 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL110723 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL110281 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL108356 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL107149 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL108231 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL307513 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL104005 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL106528 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL108525 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL432023 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL326868 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL108171 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL74962 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL110298 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL106582 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL106678 | — | IC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL106766 | — | IC50 | = | 11800.0 | nM | 4.93 |