Assay Detail
Binding
CHEMBL641571
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Binding Affinity for adenosine A2A receptor expressed in HEK293 cells compared to [3H]CGS-21680
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.52 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27508 | — | — | 1 | 7.15 |
| CHEMBL440115 | FK453 | 1.0 | 1 | 5.89 |
| CHEMBL52735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27508 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL440115 | FK453 | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL52735 | — | Ki | > | 10000.0 | nM | - |