Assay Detail
Binding
CHEMBL641572
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Binding affinity against H278D human adenosine A2A receptor stably transfected in CHO cells using [3H]- ZM-241385 as radioligand.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.66 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | — | 1 | 9.39 |
| CHEMBL464859 | NECA | — | 1 | 7.72 |
| CHEMBL144521 | — | — | 1 | 7.23 |
| CHEMBL132629 | — | — | 1 | 7.06 |
| CHEMBL129903 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL464859 | NECA | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL144521 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL132629 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL129903 | — | Ki | = | 121.0 | nM | 6.92 |