Assay Detail
Binding
CHEMBL641715
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Affinity for the Adenosine A1 receptor in the absence of GTP (A1-GTP) by using [3H]DPCPX as radioligand
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.18 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 8.23 |
| CHEMBL139000 | (R)-PIA | — | 1 | 7.96 |
| CHEMBL150197 | — | — | 1 | 7.16 |
| CHEMBL2112619 | — | — | 1 | 6.96 |
| CHEMBL607763 | — | — | 1 | 6.52 |
| CHEMBL2112665 | — | — | 1 | 6.51 |
| CHEMBL2112569 | — | — | 1 | 6.46 |
| CHEMBL443485 | 5'-Deoxyadenosine | — | 1 | 5.74 |
| CHEMBL1790733 | — | — | 1 | 5.73 |
| CHEMBL305686 | CORDYCEPIN | 1.0 | 1 | 5.15 |
| CHEMBL2112664 | — | — | 1 | 5.08 |
| CHEMBL128173 | — | — | 1 | 5.07 |
| CHEMBL1790730 | — | — | 1 | 5.05 |
| CHEMBL65976 | — | — | 1 | 4.90 |
| CHEMBL128681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL139000 | (R)-PIA | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL150197 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2112619 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL607763 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2112665 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL2112569 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL443485 | 5'-Deoxyadenosine | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL1790733 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL305686 | CORDYCEPIN | Ki | = | 7120.0 | nM | 5.15 |
| CHEMBL2112664 | — | Ki | = | 8260.0 | nM | 5.08 |
| CHEMBL128173 | — | Ki | = | 8450.0 | nM | 5.07 |
| CHEMBL1790730 | — | Ki | = | 8940.0 | nM | 5.05 |
| CHEMBL65976 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL128681 | — | Ki | = | 91.0 | % | - |