Assay Detail
Binding
CHEMBL641719
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Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H](R)-PIA displacement.
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New base-altered adenosine analogues: Synthesis and affinity at adenosine A1 and A2A receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.31 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88439 | — | — | 1 | 9.05 |
| CHEMBL610971 | — | — | 1 | 8.62 |
| CHEMBL321536 | — | — | 1 | 8.57 |
| CHEMBL423315 | — | — | 1 | 8.45 |
| CHEMBL313306 | — | — | 1 | 8.31 |
| CHEMBL313806 | — | — | 1 | 8.14 |
| CHEMBL104580 | — | — | 2 | 8.10 |
| CHEMBL611882 | — | — | 1 | 7.64 |
| CHEMBL610970 | — | — | 1 | 7.15 |
| CHEMBL607753 | — | — | 1 | 6.95 |
| CHEMBL607752 | — | — | 1 | 6.86 |
| CHEMBL608330 | — | — | 1 | 6.65 |
| CHEMBL612197 | — | — | 1 | 6.34 |
| CHEMBL610401 | — | — | 1 | 6.00 |
| CHEMBL610681 | — | — | 1 | 4.81 |
| CHEMBL236757 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88439 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL610971 | — | Ki | = | 2.41 | nM | 8.62 |
| CHEMBL321536 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL423315 | — | Ki | = | 3.55 | nM | 8.45 |
| CHEMBL313306 | — | Ki | = | 4.89 | nM | 8.31 |
| CHEMBL313806 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL104580 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL104580 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL611882 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL610970 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL607753 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL607752 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL608330 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL612197 | — | Ki | = | 452.0 | nM | 6.34 |
| CHEMBL610401 | — | Ki | = | 989.0 | nM | 6.00 |
| CHEMBL610681 | — | Ki | = | 15500.0 | nM | 4.81 |
| CHEMBL236757 | — | Ki | = | 29700.0 | nM | 4.53 |