Assay Detail
Binding
CHEMBL641721
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]R-PIA from rat brain membrane Adenosine A1 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.26 | 8.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284969 | — | — | 1 | 8.88 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 8.82 |
| CHEMBL27952 | — | — | 1 | 8.30 |
| CHEMBL284216 | — | — | 1 | 8.06 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 8.00 |
| CHEMBL307199 | — | — | 1 | 7.73 |
| CHEMBL66393 | — | — | 1 | 7.70 |
| CHEMBL417292 | — | — | 1 | 7.16 |
| CHEMBL27809 | — | — | 1 | 6.85 |
| CHEMBL287321 | — | — | 1 | 5.78 |
| CHEMBL49935 | ARISTEROMYCIN | — | 1 | 5.20 |
| CHEMBL71385 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284969 | — | Ki | = | 1.33 | nM | 8.88 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL27952 | — | Ki | = | 5.06 | nM | 8.30 |
| CHEMBL284216 | — | Ki | = | 8.76 | nM | 8.06 |
| CHEMBL477 | ADENOSINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL307199 | — | Ki | = | 18.5 | nM | 7.73 |
| CHEMBL66393 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL417292 | — | Ki | = | 69.2 | nM | 7.16 |
| CHEMBL27809 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL287321 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL49935 | ARISTEROMYCIN | Ki | = | 6260.0 | nM | 5.20 |
| CHEMBL71385 | — | Ki | = | 25900.0 | nM | 4.59 |