Assay Detail
Binding
CHEMBL641817
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Displacement of [3H]DPCPX from adenosine A1 receptor in human brain cortical membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.09 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97687 | — | — | 1 | 6.47 |
| CHEMBL97624 | — | — | 1 | 6.35 |
| CHEMBL97760 | — | — | 1 | 6.17 |
| CHEMBL102429 | — | — | 1 | 5.86 |
| CHEMBL104998 | — | — | 1 | 5.84 |
| CHEMBL103150 | — | — | 1 | 5.84 |
| CHEMBL321330 | — | — | 1 | - |
| CHEMBL97904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97687 | — | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL97624 | — | Ki | = | 448.0 | nM | 6.35 |
| CHEMBL97760 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL102429 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL104998 | — | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL103150 | — | Ki | = | 1447.0 | nM | 5.84 |
| CHEMBL321330 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL97904 | — | Ki | > | 10000.0 | nM | - |