Assay Detail
Binding
CHEMBL641884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of acetylcholinesterase from rat striatal tissue
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro acetylcholinesterase inhibitory activity of some 1-substituted analogues of velnacrine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.16 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96643 | — | — | 1 | 6.71 |
| CHEMBL328904 | — | — | 1 | 6.53 |
| CHEMBL319797 | — | — | 1 | 6.31 |
| CHEMBL329526 | — | — | 1 | 5.72 |
| CHEMBL51934 | VELNACRINE | 2.0 | 1 | 5.44 |
| CHEMBL96889 | — | — | 1 | 5.32 |
| CHEMBL96375 | — | — | 1 | 5.32 |
| CHEMBL328695 | — | — | 1 | 5.32 |
| CHEMBL262039 | — | — | 1 | 5.09 |
| CHEMBL96774 | — | — | 1 | 5.08 |
| CHEMBL329465 | — | — | 1 | 5.07 |
| CHEMBL321339 | — | — | 1 | 4.93 |
| CHEMBL540697 | — | — | 1 | 4.90 |
| CHEMBL96124 | — | — | 1 | 4.75 |
| CHEMBL92563 | — | — | 1 | 4.73 |
| CHEMBL96588 | — | — | 1 | 4.70 |
| CHEMBL330188 | — | — | 1 | 4.42 |
| CHEMBL95161 | — | — | 1 | 4.31 |
| CHEMBL96861 | — | — | 1 | 4.29 |
| CHEMBL95066 | — | — | 1 | 4.19 |
| CHEMBL329069 | — | — | 1 | - |
| CHEMBL419146 | — | — | 1 | - |
| CHEMBL96196 | — | — | 1 | - |
| CHEMBL96406 | — | — | 1 | - |
| CHEMBL329576 | — | — | 1 | - |
| CHEMBL96542 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96643 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL328904 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL319797 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL329526 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL51934 | VELNACRINE | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL96889 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL96375 | — | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL328695 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL262039 | — | IC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL96774 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL329465 | — | IC50 | = | 8590.0 | nM | 5.07 |
| CHEMBL321339 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL540697 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL96124 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL92563 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL96588 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL330188 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL95161 | — | IC50 | = | 48800.0 | nM | 4.31 |
| CHEMBL96861 | — | IC50 | = | 51800.0 | nM | 4.29 |
| CHEMBL95066 | — | IC50 | = | 64900.0 | nM | 4.19 |
| CHEMBL329069 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL419146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL96196 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL96406 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL329576 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL96542 | — | IC50 | > | 100000.0 | nM | - |