Assay Detail
Binding
CHEMBL641885
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Inhibition of rat acetylcholinesterase (AChE)
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.80 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340427 | XANTHOSTIGMINE | — | 1 | 9.52 |
| CHEMBL128202 | — | — | 1 | 9.25 |
| CHEMBL131579 | — | — | 1 | 9.15 |
| CHEMBL337999 | — | — | 1 | 9.09 |
| CHEMBL131827 | — | — | 1 | 8.96 |
| CHEMBL128260 | — | — | 1 | 8.55 |
| CHEMBL131219 | — | — | 1 | 8.40 |
| CHEMBL128471 | — | — | 1 | 8.24 |
| CHEMBL340625 | — | — | 1 | 8.24 |
| CHEMBL339039 | — | — | 1 | 8.07 |
| CHEMBL128618 | — | — | 1 | 8.05 |
| CHEMBL130918 | — | — | 1 | 8.05 |
| CHEMBL128863 | — | — | 1 | 7.89 |
| CHEMBL440526 | — | — | 1 | 7.89 |
| CHEMBL128551 | — | — | 1 | 7.85 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.85 |
| CHEMBL128552 | — | — | 1 | 7.68 |
| CHEMBL336297 | — | — | 1 | 7.55 |
| CHEMBL128043 | — | — | 1 | 7.51 |
| CHEMBL130847 | — | — | 1 | 7.44 |
| CHEMBL129753 | — | — | 1 | 7.43 |
| CHEMBL128390 | — | — | 1 | 7.38 |
| CHEMBL132110 | — | — | 1 | 7.17 |
| CHEMBL128452 | — | — | 1 | 7.16 |
| CHEMBL128780 | — | — | 1 | 7.00 |
| CHEMBL131411 | — | — | 1 | 7.00 |
| CHEMBL131253 | — | — | 1 | 7.00 |
| CHEMBL127960 | — | — | 1 | 6.80 |
| CHEMBL129577 | — | — | 1 | 6.77 |
| CHEMBL128392 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340427 | XANTHOSTIGMINE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL128202 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL131579 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL337999 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL131827 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL128260 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL131219 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL128471 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL340625 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL339039 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL128618 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL130918 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL128863 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL440526 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL128551 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL128552 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL336297 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL128043 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL130847 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL129753 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL128390 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL132110 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL128452 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL128780 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL131411 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL131253 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL127960 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL129577 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL128392 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL421282 | — | IC50 | = | 400.0 | nM | 6.40 |